Willow-Funded Preliminary Research Yields Promising Data about Nutrition and Cancer
Willow's 2018 beneficiary, Dr. Nicole Simone, has made promising strides in the field of cancer research. She and her team have determined that changing your diet improves breast cancer outcomes. What if your physician could prescribe the ideal diet based on your cancer? Although diets have been used in clinical trials with breast cancer, for the first time, Dr. Simone and her team aim to understand how diet can change breast cancer at the molecular level to affect positive changes in a patient's outcome.
Preliminary results have identified micro-RNA-21 to be correlated to breast cancer progression and metastasis. By some estimates, miR-21 can be linked to 15-20% of cancer deaths worldwide. Dr. Simone's research has determined six foods, spices and minerals that decreases miR-21: Magnesium, Vitamin D, Omega-3 fatty acids, Vitamin C, Vitamin B6, and Zinc. Additionally, her research suggests that Iron, Carbohydrates, Vitamin B12 and Total Fat may increase miR-21.
Her team's next steps include synthesizing metastatic cancer tissues into organoids and exposing them to nutritional panels to determine the effect on tumor cell proliferation. Should they succeed, they will seek to recruit patients for a clinical trial to utilize precision nutrition to improve cancer outcomes for metastatic cancer patients.